The San Diego Padres (71-56) and San Francisco Giants (61-66) will meet on Thursday at PETCO Park, with first pitch at 4:10 p.m. ET.
The Padres are the home favorite (-139) versus the Giants (+118). The Padres will start Dylan Cease (5-11) against the Giants and Justin Verlander (1-9).
Yesterday, the Padres claimed an 8-1 win over the Giants, with JP Sears (6.0 IP, 1 R, 4 H, 2 K) earning the win for the Padres. Gavin Sheets went 2 for 4 with two home runs and four RBIs to lead the offensive showing. Landen Roupp (2.1 IP, 5 R, 5 H, 2 K) picked up the loss for the Giants.
Before watching this Padres vs. Giants matchup, here is what you need to know about Thursday’s action on the diamond, including viewing options.
San Diego Padres vs. San Francisco Giants odds, line and spread
MLB odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 12:22 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Favorite: Padres (-139, bet $139 to win $100)Underdog: Giants (+118, bet $100 to win $118)Over/under: 8
Padres vs. Giants: Game time and live stream info
Game day: Thursday, August 21, 2025Game time: 4:10 p.m. ETLocation: San Diego, CaliforniaStadium: PETCO ParkTV channel: SDPA and NBCS-BALive stream: Watch LIVE with Fubo! (Regional restrictions may apply)
Watch Padres vs. Giants on Fubo!
Padres stats and trends
Padres betting records
The Padres have been favorites in 69 games this season and won 42 (60.9%) of those contests.San Diego has entered 43 games this season favored by -139 or more and is 27-16 in those contests.Bookmakers have implied with the moneyline set for this matchup that the Padres have a 58.2% chance to win.San Diego’s games have gone over the total in 52 of its 127 chances.The Padres are 71-56-0 against the spread in their 127 chances this season.
Dylan Cease (Padres probable starter)
Cease (5-11 with a 4.61 ERA and 171 strikeouts in 132 2/3 innings pitched) makes the start for the Padres, his 26th of the season.In his most recent appearance on Sunday against the Los Angeles Dodgers, the righty tossed 3 1/3 innings, giving up three earned runs while surrendering two hits.The 29-year-old has an ERA of 4.61, with 11.6 strikeouts per nine innings, in 25 games this season. Opponents have a .235 batting average against him.Cease is looking to collect his eighth quality start of the year.Cease will try to pick up his 18th matchup of five or more innings pitched this season. He averages 5.3 innings per appearance.In three of his 25 total appearances this season he has not surrendered an earned run.He meets a Giants offense that ranks 25th in the league with 511 runs while batting .231 as a squad. It has a collective .374 slugging percentage (27th in MLB action) and has hit a total of 121 home runs (25th in MLB).Cease has thrown five innings, giving up three earned runs on five hits while striking out seven against the Giants this season.The 29-year-old ranks 49th in ERA (4.61), 44th in WHIP (1.312), and second in K/9 (11.6) among qualifying pitchers in MLB action this season.
Padres batting stats
The Padres rank 29th in Major League Baseball with just 110 home runs as a team.Hitters for San Diego have combined for a team rank of 25th in the majors with a .385 team slugging percentage.The Padres’ .251 batting average is among the best in baseball, ranking eighth in MLB.San Diego ranks 22nd in the majors with 531 total runs scored this season.The Padres have an OBP of .322 this season, which ranks eighth in MLB.San Diego ranks third in MLB in strikeouts per game with an average of 7.0 whiffs per contest.
Giants stats and trends
Giants betting records
The Giants have won in 23, or 46%, of the 50 contests they have been named as odds-on underdogs this year.San Francisco has a mark of 10-12 in contests where bookmakers favor it by +118 or worse on the moneyline.The moneyline set for this matchup implies the Giants have a 45.9% chance of coming away with a victory in the contest.San Francisco and its opponents have gone over the total this season in 57 of its 127 opportunities.The Giants are 53-74-0 against the spread in their 127 games with a line set by sportsbooks this season.
Justin Verlander (Giants probable starter)
Verlander makes the start for the Giants, his 22nd of the season. He is 1-9 with a 4.32 ERA and 95 strikeouts in 106 1/3 innings pitched.His last time out was on Sunday against the Tampa Bay Rays, when the righty tossed seven scoreless innings while giving up two hits.The 42-year-old has a 4.32 ERA and 8.0 strikeouts per nine innings during 21 games this season, while allowing a batting average of .275 to opposing hitters.Verlander is trying to secure his eighth quality start of the season in this game.Verlander is seeking his sixth straight appearance lasting five or more innings. He averages 5.1 innings per start.He has held his opponents without an earned run in three of his 21 appearances this season.He will take the hill against a Padres offense that ranks 15th in the league with 1067 total hits (on a .251 batting average). The squad also slugs a collective .385 (25th in the league) with 110 total home runs (29th in MLB action).
Giants batting stats
The Giants average 1.0 home run per game to rank 25th in MLB play with 121 total home runs.So far this year, San Francisco’s .374 slugging percentage is the fourth-lowest percentage in the majors.The Giants rank 28th in MLB with a .231 batting average.Averaging 4.0 runs per game (511 total), San Francisco is the 25th-highest scoring team in baseball.The Giants’ .307 on-base percentage ranks 22nd in MLB.
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