Five NFL games we can’t wait to watch in the 2025 season
The schedule for the 2025 NFL season has been released. Here are a few games on our must-watch list.
Who will win the Seattle Seahawks vs the San Francisco 49ers game?
The San Francisco 49ers and Seattle Seahawks play on Sunday, Sept. 7, at the Seahawks’ Lumen Field in a game on the NFL Week 1 schedule.
What do NFL Week 1 odds say about the game? Who are the NFL Week 1 predictions and NFL Week 1 picks taking in the game?
Which team has the best chance to win the game according to NFL Week 1 win probabilities?
Check out The Arizona Republic’s score prediction for the Sunday football game, as well as 49ers vs Seahawks picks, odds and win chances for the NFL Week 1 game, which can be seen at 1:05 p.m. MST on FOX (stream with FUBO).
NFL Week 1 predictions: Eagles vs Cowboys | Chargers vs Chiefs | Falcons vs Buccaneers | Browns vs Bengals | Colts vs Dolphins | Jaguars vs Panthers | Patriots vs Raiders | Saints vs Cardinals | Jets vs Steelers | Commanders vs Giants | Broncos vs Titans | Seahawks vs 49ers | Packers vs Lions | Rams vs Texans | Bills vs Ravens | Bears vs Vikings | Win probabilities | Score picks
Watch 49ers at Seahawks on FUBO (free trial)
San Francisco 49ers vs Seattle Seahawks prediction
The Arizona Republic is predicting a 24-23 win for the Seahawks over the 49ers in the NFL Week 1 Sunday football game.
Jeremy Cluff writes: “The Seahawks decided to go with Sam Darnold at QB. Was it the right move? Seattle could end up looking really smart after this game.”
Seattle Seahawks vs San Francisco 49ers picks
Will the 49ers or Seahawks win the game in NFL Week 1?
Bookies.com says to bet the 49ers to cover the point spread against the Seahawks on Sunday.
Sports Betting Dime’s formula predicts a 2-point win for the Seahawks over the 49ers in the NFL Week 1 game.
Dimers.com predicts a final score of 49ers 23, Seahawks 21.
Fansided’s prediction for the game is a 24-20 victory for the 49ers over the Seahawks.
NFL Week 1 picks: Cowboys vs Eagles | Chiefs vs Chargers | Buccaneers vs Falcons | Bengals vs Browns | Dolphins vs Colts | Panthers vs Jaguars | Raiders vs Patriots | Cardinals vs Saints | Steelers vs Jets | Giants vs Commanders | Titans vs Broncos | 49ers vs Seahawks | Lions vs Packers | Texans vs Rams | Ravens vs Bills | Vikings vs Bears | The Republic’s score predictions
San Francisco 49ers vs Seattle Seahawks win probabilities
The 49ers have a 53.7% chance to beat the Seahawks on Sunday, according to ESPN.
The site gives the Seahawks a 45.9% shot at winning the NFL Week 1 game, with the remaining percentage accounting for a tie.
Seattle Seahawks vs San Francisco 49ers odds
The 49ers are a 2.5-point favorite over the Seahawks in NFL Week 1 odds for the game, courtesy of BetMGM Sportsbook.
San Francisco is -135 on the moneyline, while Seattle is +115.
The over/under (point total) is set at 45.5 points.
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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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