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San Francisco 49ers injury report: QB Brock Purdy questionable

September 19, 2025
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San Francisco 49ers injury report: QB Brock Purdy questionable
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The 49ers are shorthanded offensively as they face the Cardinals in Week 3.

The San Francisco 49ers completed the practice week on Friday for Sunday’s game against the Arizona Cardinals, and they released their final injury report. Their offensive depth is being tested. Quarterback Brock Purdy is not expected to play, while left guard Connor Colby was added to the report on Friday.

The details of the 49ers’ final injury report are below. After each player’s injury, there is the daily status, which is either no status (NS), did not practice (DNP), limited (LIM) or Full.

Starters are noted with an asterisk.

San Francisco 49ers Week 3 injury report: Ruled out

G Spencer Burford (knee): DNP all three daysWR Jordan Watkins (calf): NS, LIM, DNP

With depth already being tested at wide receiver, Watkins was added to the injury report Thursday and was declared out Friday.

Questionable

LG Connor Colby (groin): NS, NS, LIM*WR Jauan Jennings (ankle/shoulder): DNP all three daysQB Brock Purdy (toe/left shoulder): LIM all three days

After Purdy was limited for the third consecutive day, head coach Kyle Shanahan did say he’s made “a lot of progress. I thought he had a good week. Hopefully we can get him up for the game. We’ll see how he does tomorrow. Just talking to him, I think it’s highly unlikely that he’ll start. But, just trying to see where he is at to see if he could be a two or an emergency three.” Adrian Martinez was elevated from the practice squad last week.

Colby played most of the game in Week 2 after Ben Bartch left with a high-ankle sprain and was placed on injured this week. Now, Colby is hobbled with the groin issue, apparently suffered in practice Thursday.

Asked who would play if Colby can’t, Shanahan said, “It will be a surprise for everyone. But, it could be (undrafted rookie free agent) Drew Moss, it could be (Nick) Zakelj, could have been Spencer (Burford), but he went down. There are some more guys I could probably mention, but most likely one of those two.”

Jennings didn’t practice all week.

No injury designation

*DE Nick Bosa (not injury related/rest): DNP, Full, FullDE Yetur Gross-Matos (knee): DNP, LIM, DNPRB Jordan James (finger): Full all three daysFB Kyle Juszczyk (concussion): DNP, LIM, Full*RB Christian McCaffrey (calf/not injury related/rest: DNP, Full, FullS Siran Neal (concussion): DNP, LIM, Full*T Trent Williams (knee/not injury related/rest: DNP, LIM, Full

With issues in the passing game and tight end George Kittle also on injured reserve, McCaffrey will be counted on for a big load on offense. Since being acquired in a trade during the 2022 season, the 49ers are 29-10 in games he’s played including the playoffs and 5-9 when he hasn’t played.

Arizona Cardinals Friday injury report

Doubtful

CB Will Johnson (groin): DNP all three days

Questionable

G Will Hernandez (knee): LIM all three days*LT Paris Johnson Jr. (knee): LIM all three days*CB Max Melton (knee): LIM all three daysTE Tip Reiman (foot): LIM all three days

No injury designation

T Kelvin Beachum (not injury related/rest): LIM, Full, NSLB Cody Simon (concussion): LIM, Full, FullDL Dante Stills (elbow): LIM, Full, Full

Get more Cardinals and NFL coverage from Cards Wire’s Jess Root and others by listening to the latest on the Rise Up, See Red podcast. Subscribe on Spotify, YouTube or Apple podcasts.



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Tags:49ersBrockFranciscoINJURYPurdyQuestionableReportSan

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