The San Francisco 49ers (2-0) host an NFC West showdown against the Arizona Cardinals (2-0) on Sunday, September 21, 2025 at Levi’s Stadium.
What channel is 49ers vs. Cardinals on?
Location: Levi’s Stadium in Santa Clara, CaliforniaDate: Sept. 21Time: 4:25 p.m. ETTV channel: FOXLive stream: Fubo (Regional restrictions may apply)Live stream: Sling
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What time is 49ers vs. Cardinals?
The 49ers and the Cardinals play at 4:25 p.m. ET.
49ers vs. Cardinals betting odds, lines, spread
The latest odds can be found below:
49ers vs. Cardinals recent matchups
In their last five head-to-head bouts, San Francisco has taken down Arizona three times.The 49ers have a 3-2 record ATS in those games, while the two teams have gone over the point total on four occasions.Arizona has been outpaced by 36 points in its last five tilts versus San Francisco.1/5/2025: Cardinals 47, 49ers 2410/6/2024: Cardinals 24, 49ers 2312/17/2023: 49ers 45, Cardinals 2910/1/2023: 49ers 35, Cardinals 161/8/2023: 49ers 38, Cardinals 13
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49ers schedule
WeekDateOpponentTime (ET)TV ChannelLive Stream/Result1Sept. 7@ Seahawks—-Win, 17-132Sept. 14@ Saints—-Win, 26-213Sept. 21vs. Cardinals4:25 p.m. ETFOXFubo | Sling4Sept. 28vs. Jaguars4:05 p.m. ETFOXFubo | Sling5Oct. 2@ Rams8:15 p.m. ETAmazon Prime VideoPrime Video6Oct. 12@ Buccaneers1 p.m. ETCBSParamount+ | Fubo7Oct. 19vs. Falcons8:20 p.m. ETNBCPeacock | Fubo | Sling8Oct. 26@ Texans1 p.m. ETFOXFubo | Sling9Nov. 2@ Giants1 p.m. ETCBSParamount+ | Fubo10Nov. 9vs. Rams4:25 p.m. ETFOXFubo | Sling11Nov. 16@ Cardinals4:05 p.m. ETFOXFubo | Sling12Nov. 24vs. Panthers8:15 p.m. ETESPNFubo | Sling13Nov. 30@ Browns1 p.m. ETCBSParamount+ | Fubo15Dec. 14vs. Titans4:25 p.m. ETFOXFubo | Sling16Dec. 22@ Colts8:15 p.m. ETESPNFubo | Sling17Dec. 28vs. Bears8:20 p.m. ETNBCPeacock | Fubo | Sling18TBDvs. SeahawksTBDTBD–
Cardinals schedule
WeekDateOpponentTime (ET)TV ChannelLive Stream/Result1Sept. 7@ Saints—-Win, 20-132Sept. 14vs. Panthers—-Win, 27-223Sept. 21@ 49ers4:25 p.m. ETFOXFubo | Sling4Sept. 25vs. Seahawks8:15 p.m. ETAmazon Prime VideoPrime Video5Oct. 5vs. Titans4:05 p.m. ETCBSParamount+ | Fubo6Oct. 12@ Colts1 p.m. ETFOXFubo | Sling7Oct. 19vs. Packers4:25 p.m. ETFOXFubo | Sling9Nov. 3@ Cowboys8:15 p.m. ETABC/ESPNFubo | Sling10Nov. 9@ Seahawks4:05 p.m. ETCBSParamount+ | Fubo11Nov. 16vs. 49ers4:05 p.m. ETFOXFubo | Sling12Nov. 23vs. Jaguars4:05 p.m. ETCBSParamount+ | Fubo13Nov. 30@ Buccaneers1 p.m. ETFOXFubo | Sling14Dec. 7vs. Rams4:25 p.m. ETFOXFubo | Sling15Dec. 14@ Texans1 p.m. ETFOXFubo | Sling16Dec. 21vs. Falcons4:05 p.m. ETFOXFubo | Sling17TBD@ BengalsTBDTBD–18TBD@ RamsTBDTBD–
NFL week 3 schedule
Miami Dolphins at Buffalo Bills: Thursday at 8:15 p.m. ETHouston Texans at Jacksonville Jaguars: Sunday at 1 p.m. ETPittsburgh Steelers at New England Patriots: Sunday at 1 p.m. ETNew York Jets at Tampa Bay Buccaneers: Sunday at 1 p.m. ETAtlanta Falcons at Carolina Panthers: Sunday at 1 p.m. ETLas Vegas Raiders at Washington Commanders: Sunday at 1 p.m. ETIndianapolis Colts at Tennessee Titans: Sunday at 1 p.m. ETLos Angeles Rams at Philadelphia Eagles: Sunday at 1 p.m. ETGreen Bay Packers at Cleveland Browns: Sunday at 1 p.m. ETCincinnati Bengals at Minnesota Vikings: Sunday at 1 p.m. ETDenver Broncos at Los Angeles Chargers: Sunday at 4:05 p.m. ETNew Orleans Saints at Seattle Seahawks: Sunday at 4:05 p.m. ETDallas Cowboys at Chicago Bears: Sunday at 4:25 p.m. ETArizona Cardinals at San Francisco 49ers: Sunday at 4:25 p.m. ETKansas City Chiefs at New York Giants: Sunday at 8:20 p.m. ETDetroit Lions at Baltimore Ravens: Monday at 8:15 p.m. ET
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