The Arizona Cardinals and San Francisco 49ers play on Sunday, Sept. 21, in a game on the NFL Week 3 schedule.
Here’s a look at the time, TV channel and broadcast information for the Week 3 NFL game, which will be played at the 49ers’ Levi’s Stadium.
The 49ers are a 1.5-point favorite over the Cardinals in NFL Week 3 odds for the game, according to BetMGM Sportsbook. San Francisco is -120 on the moneyline, while Arizona is +100. The over/under for the game is set at 43.5 points.
The Cardinals are coming off a 27-22 win against the Carolina Panthers in NFL Week 2. The 49ers beat the New Orleans Saints, 26-21
Here’s how to watch the Cardinals vs 49ers game on television and how to stream the game on streaming services:
NFL Week 3 picks: Dolphins at Bills | Falcons at Panthers | Packers at Browns | Texans at Jaguars | Bengals at Vikings | Steelers at Patriots | Rams at Eagles | Jets at Buccaneers | Colts at Titans | Raiders at Commanders | Broncos at Chargers | Saints at Seahawks | Cowboys at Bears | Cardinals at 49ers | Chiefs at Giants | Lions at Ravens | The Republic’s score predictions
Watch Cardinals at 49ers on FUBO (free trial)
What channel is Arizona Cardinals vs San Francisco 49ers game on today? Time, TV schedule
TV channel: FOX
Start time: 1:25 p.m. MST (Arizona), 4:25 p.m. ET
How to watch Arizona Cardinals vs San Francisco 49ers game on livestream
The game can be streamed on streaming services that carry FOX, including FUBO, which offers a free trial, and Sling.
Who are the announcers for the Arizona Cardinals vs San Francisco 49ers NFL Week 3 game?
Adam Amin (play-by-play) and Mark Sanchez (analyst) are scheduled to be the announcers for the 49ers vs Cardinals Week 3 NFL game today.
Arizona Cardinals schedule 2025 (all times MST)
NFL Week 3: Sunday, Sept. 21 at San Francisco 49ers, Fox, 1:25 p.m.NFL Week 4: Thursday, Sept. 25 vs. Seattle Seahawks, Prime Video, 5:15 p.m.NFL Week 5: Sunday, Oct. 5 vs. Tennessee Titans, CBS, 1:05 p.m.NFL Week 6: Sunday, Oct. 12 at Indianapolis Colts, Fox, 10 a.m.NFL Week 7: Sunday, Oct. 19 vs. Green Bay Packers, Fox, 1:25 p.m.NFL Week 8: OFFNFL Week 9: Monday, Nov. 3 at Dallas Cowboys, ESPN/ABC, 6:15 p.m.NFL Week 10: Sunday, Nov. 9 at Seattle Seahawks, CBS, 2:05 p.m.NFL Week 11: Sunday, Nov. 16 vs. San Francisco 49ers, Fox, 2:05 p.m.NFL Week 12: Sunday, Nov. 23 vs. Jacksonville Jaguars, CBS, 2:05 p.m.NFL Week 13: Sunday, Nov. 30 at Tampa Bay Buccaneers, Fox, 11 a.m.NFL Week 14: Sunday, Dec. 7 vs. Los Angeles Rams, Fox, 2:25 p.m.NFL Week 15: Sunday, Dec. 14 at Houston Texans, Fox, 11 a.m.NFL Week 16: Sunday, Dec. 21 vs. Atlanta Falcons, Fox, 2:05 p.m.NFL Week 17: Saturday or Sunday, Dec. 27-28 at Cincinnati Bengals, TBDNFL Week 18: Saturday or Sunday, Jan. 3-4 at Los Angeles Rams, TBD
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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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