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Los Angeles Rams vs San Francisco 49ers predictions, odds, and picks for Week 5 TNF clash

October 2, 2025
inSport
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The Los Angeles Rams and San Francisco 49ers both look like they’re in vintage form, with both teams coming off a 3-1 start. However, only one team will emerge victorious. There are plenty of storylines going into the game, from the banged-up 49ers offense to the Rams’ re-emergence of Puka Nacua. Here’s a look at everything you need to know about the contest.

Los Angeles Rams vs San Francisco 49ers: Game Details

Fixture: 49ers at Rams on TNF

•

Date & Time: Thursday, October 2 at 8:15 PM ET

Looking to predict NFL playoff Scenarios? Try our NFL Playoff Predictor for real-time simulations and stay ahead of the game!

Venue: Sofi Stadium in Inglewood, California

Los Angeles Rams vs San Francisco 49ers: Betting Odds (via BetMGM)

Spread

Rams (-7)

49ers (+7)

Moneyline

Rams (-325)

49ers (+260)

Total

Over/Under (47.5)

Los Angeles Rams vs San Francisco 49ers: Picks

Puka Nacua at Indianapolis Colts at Los Angeles Rams - Source: Imagn

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About the author

” data-lazy=”https://keedag.sportskeeda.com/user-pic/466823-1717095362-200.jpg?w=200″
alt=”Ian Van Roy” height=”72″ width=”72″>

Ian brings with him more than 6.5 years of sports writing experience to the Sportskeeda NFL team. He played offensive line in middle school and high school, and also made it to the top 0% matchmaking ranking in MUT play in Madden.

He possesses the quality of identifying unique story angles from quotes in press conferences, social media and interviews. He assimilates facts for his stories with a lawyer-like precision and verifies each and every piece of information.

Ian admires Peyton Manning for his ability to beat teams with his mind despite not being the best athlete, and is also a fan of Tom Brady. The Denver Broncos are his favorite team, and their Super Bowl 50 win in Manning’s last game is etched in his memory forever. Bill Belichick is his all-time favorite coach.

He has also grown to admire the Los Angeles Rams mainly because he and Cooper Kupp went to the same college, Eastern Washington University, with both finishing their college careers at the same time.

In his career so far, Ian has had the privilege of exclusively interviewing Los Angeles Rams General Manager Les Snead, Kwity Paye of the Indianpolis Colts and Cleveland Browns wide receiver Jamari Thrash. When not writing, he likes to play video games and be outdoors.

Know More

Edited by Ian Van Roy



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