The Tampa Bay Buccaneers (4-1) square off against the San Francisco 49ers (4-1) at Raymond James Stadium on Sunday, October 12, 2025.
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Tampa Bay Buccaneers vs. San Francisco 49ers game info
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How to buy Buccaneers vs. 49ers tickets for NFL Week 6
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Tampa Bay Buccaneers vs. San Francisco 49ers betting odds, lines, spreads
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Tampa Bay Buccaneers schedule
Week 1: Sept. 7 at Atlanta Falcons, 23-20 winWeek 2: Sept. 15 at Houston Texans, 20-19 winWeek 3: Sept. 21 vs. New York Jets, 29-27 winWeek 4: Sept. 28 vs. Philadelphia Eagles, 31-25 lossWeek 5: Oct. 5 at Seattle Seahawks, 38-35 winWeek 6: Oct. 12 at 4:25 p.m. ET vs. San Francisco 49ersWeek 7: Oct. 20 at 7 p.m. ET at Detroit LionsWeek 8: Oct. 26 at 4:05 p.m. ET at New Orleans SaintsWeek 10: Nov. 9 at 1 p.m. ET vs. New England PatriotsWeek 11: Nov. 16 at 1 p.m. ET at Buffalo BillsWeek 12: Nov. 23 at 8:20 p.m. ET at Los Angeles RamsWeek 13: Nov. 30 at 1 p.m. ET vs. Arizona CardinalsWeek 14: Dec. 7 at 1 p.m. ET vs. New Orleans SaintsWeek 15: Dec. 11 at 8:15 p.m. ET vs. Atlanta FalconsWeek 16: Dec. 21 at 1 p.m. ET at Carolina PanthersWeek 17: Dec. 28 at 1 p.m. ET at Miami DolphinsWeek 18: TBD vs. Carolina Panthers
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Tampa Bay Buccaneers stats
Total offense: 353.8 yards per game, 11th in NFLPassing offense: 243.4 yards per game, sixth in NFLRushing offense: 110.4 yards per game, 22nd in NFLTotal defense: 310.8 yards per game, 11th in NFLPassing defense: 218.4 yards per game, 20th in NFLRushing defense: 92.4 yards per game, eighth in NFL
San Francisco 49ers schedule
Week 1: Sept. 7 at Seattle Seahawks, 17-13 winWeek 2: Sept. 14 at New Orleans Saints, 26-21 winWeek 3: Sept. 21 vs. Arizona Cardinals, 16-15 winWeek 4: Sept. 28 vs. Jacksonville Jaguars, 26-21 lossWeek 5: Oct. 2 at Los Angeles Rams, 26-23 winWeek 6: Oct. 12 at 4:25 p.m. ET at Tampa Bay BuccaneersWeek 7: Oct. 19 at 8:20 p.m. ET vs. Atlanta FalconsWeek 8: Oct. 26 at 1 p.m. ET at Houston TexansWeek 9: Nov. 2 at 1 p.m. ET at New York GiantsWeek 10: Nov. 9 at 4:25 p.m. ET vs. Los Angeles RamsWeek 11: Nov. 16 at 4:05 p.m. ET at Arizona CardinalsWeek 12: Nov. 24 at 8:15 p.m. ET vs. Carolina PanthersWeek 13: Nov. 30 at 1 p.m. ET at Cleveland BrownsWeek 15: Dec. 14 at 4:25 p.m. ET vs. Tennessee TitansWeek 16: Dec. 22 at 8:15 p.m. ET at Indianapolis ColtsWeek 17: Dec. 28 at 8:20 p.m. ET vs. Chicago BearsWeek 18: TBD vs. Seattle Seahawks
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San Francisco 49ers stats
Total offense: 375.8 yards per game, fifth in NFLPassing offense: 290.6 yards per game, first in NFLRushing offense: 85.2 yards per game, 28th in NFLTotal defense: 315.6 yards per game, 15th in NFLPassing defense: 207.6 yards per game, 14th in NFLRushing defense: 108 yards per game, 15th in NFL
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