The San Francisco 49ers’ string of bad luck continued during Week 6 of the 2025 NFL season, with star linebacker Fred Warner suffering a gruesome injury in a blowout loss to the Tampa Bay Buccaneers.
Warner was immediately placed in an air cast before he was loaded on a cart and taken to the locker room.
It was immediately clear that Warner would not return to the game, and now we know his official diagnosis that will end his season.
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According to Ian Rapoport of the NFL Network, Warner suffered a dislocated and broken ankle.
Oct 12, 2025; Tampa, Florida, USA; San Francisco 49ers middle linebacker Fred Warner (54) is carted off the field during the first quarter against the Tampa Bay Buccaneers at Raymond James Stadium. Mandatory Credit: Nathan Ray Seebeck-Imagn Images
49ers head coach Kyle Shanahan confirmed the devastating news during the post-game press conference.
“It’s big. Anytime you lose one of your best players, also a huge leader. So obviously it’s a huge blow,” Shanahan said when speaking to the media.
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“Feel bad for Fred right now. He’s in good spirits. He’s got a good foundation. We have a lot of faith in Tatum Bethune. He’s the next man up and he’s gonna have to do it throughout the year.”
Kyle Shanahan on losing Fred Warner:
“It’s big. Anytime you lose one of your best players, also a huge leader. So obviously it’s a huge blow. Feel bad for Fred right now. He’s in good spirits. He’s got a good foundation. We have a lot of faith in Tatum Bethune. He’s the next man… pic.twitter.com/pZnXyR5AZ0
— Coach Yac 🗣 (@Coach_Yac) October 12, 2025
This season, Warner recorded 51 total tackles, two forced fumbles, and a fumble recovery. It’s a brutal blow for a defense that was already without former Defensive Player of the Year Nick Bosa.
Up next for the 49ers is a primetime showdown against the Atlanta Falcons in Week 7 on Sunday Night Football.
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