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San Francisco 49ers vs Houston Texans picks, odds for NFL Week 8 game

October 20, 2025
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49ers RB tallies over 200 yards vs Falcons
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NFL Overreactions Week 7

USA TODAY’s Prince Grimes breaks down the best games from NFL Week 7.

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The San Francisco 49ers and Houston Texans play on Sunday, Oct. 26, at the Texans’ NRG Stadium in a game on the NFL Week 8 schedule.

Which team will win the NFL Week 8 game?

Check out these NFL Week 8 picks and NFL Week 8 predictions for the game, which can be seen at 10 a.m. MST on FOX (stream with FUBO).

The Texans are a 1-point favorite over the 49ers in NFL Week 8 odds for the game, courtesy of BetMGM Sportsbook.

Houston is -118 on the moneyline, while San Francisco is -102. The over/under (point total) is set at 42.5 points.

Watch 49ers at Texans live on FUBO (free trial)

Jeremy Cluff writes: “We keep picking against the 49ers, and they keep proving us wrong. We’re not picking against Christian McCaffrey and the 49ers with the Texans coming off a short week in this game.”

NFL Week 8 picks: Predictions, score projections for games on NFL Week 8 schedule

Bookies.com: Bet the under in Texans vs 49ers game

Bill Speros writes: “The on-again, off-again, often-injured 49ers were on again Sunday night. Christian McCaffrey stacked 200 total yards from scrimmage in San Francisco’s 20-10 over Atlanta. CMC ran for 129 of those yards and scored 2 TDs. Expect that to be the 49ers’ game plan until further notice. The Texans came off the bye Monday night but had yet to beat a team with a winning record before facing Seattle.”

NFL power rankings Week 8: Where are Houston Texans, San Francisco 49ers ranked now?

The site’s formula predicts that the Texans will win the NFL Week 8 game against the 49ers.

NFL Week 8 odds: Point spreads, moneylines, over/unders for this week

ESPN: Texans have a 57.2% chance to beat 49ers on Sunday

The site gives the 49ers a 42.4% shot at winning the NFL Week 8 game, with the remaining percentage accounting for a tie.

NFL Week 8 schedule: TV channels, how to watch games this week

Dimers: 49ers 23, Texans 21

It writes: “After extensive simulations, our model gives the 49ers a win probability of 59%, while the Texans have a win probability of 41%.”

Sportsnaut: San Francisco 49ers 20, Houston Texans 17

Matt Johnson writes: “We always love matchups between a defensive-minded head coach versus his former team, especially since this is DeMeco Ryans vs. Kyle Shanahan. The Houston Texans’ defense has been excellent this season versus the pass, and that trend will probably continue Sunday, regardless of who is starting at quarterback for the San Francisco 49ers. What Shanahan will do is feed Christian McCaffrey against a defense that is below average versus the run. Between that and Houston’s issues providing C.J. Stroud with even a few seconds in a clean pocket, we think San Francisco pulls this one out in Texas.”

NFL’s highest paid players in 2025: Quarterbacks | Running backs | Wide receivers | Tight ends | Offensive linemen | D-linemen | Cornerbacks | Safeties | Linebackers | Edge rushers | Highest paid NFL players: Overall | By position | By team

Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.

Support local journalism: Subscribe to azcentral.com today. Sign up for azcentral Preps Now. And be sure to subscribe to our daily sports newsletters so you don’t miss a thing.



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