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Los Angeles Rams vs San Francisco 49ers picks, odds for NFL Week 10

November 3, 2025
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NFL Overreactions Week 9

USAT’s Prince Grimes breaks down the biggest storylines from NFL Week 9.

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The Los Angeles Rams and San Francisco 49ers play on Sunday, Nov. 9, at the 49ers’ Levi’s Stadium in a game on the NFL Week 10 schedule.

Which team will win the NFL Week 10 game?

Check out these NFL Week 10 picks and NFL Week 10 predictions for the game, which can be seen at 2:25 p.m. MST on FOX (stream with FUBO).

The Rams are a 3.5-point favorite over the 49ers in NFL Week 10 odds for the game, courtesy of BetMGM Sportsbook.

Los Angeles is -190 on the moneyline, while San Francisco is +155. The over/under (point total) is set at 49.5 points.

NFL Week 10 picks: Raiders at Broncos | Falcons vs Colts | Saints at Panthers | Giants at Bears | Jaguars at Texans | Bills at Dolphins | Ravens at Vikings | Browns at Jets | Patriots at Buccaneers | Cardinals at Seahawks | Rams at 49ers | Lions at Commanders | Steelers at Chargers | Eagles at Packers | Score predictions

Watch Rams at 49ers live on FUBO (free trial)

Jeremy Cluff writes: “The 49ers won a thriller over the Rams earlier this season in Los Angeles, 26-23. The Rams will repay the favor with a close win over the 49ers in Santa Clara. Matthew Stafford and the LA offense are just clicking right now.”

NFL Week 10 picks: Predictions, score projections for who wins every NFL game this week

Bookies.com: Bet the 49ers with the points vs Rams

Bill Speros writes: “The Rams tore up the Saints Sunday, scoring in all 4 quarters during a 34-10 walk-over. Matt Stafford threw for 284 yards and 4 TDs. The 49ers ran over and through the Giants at MetLife, but gave up 14 points in the 4th quarter in a 34-24 win. CMC amassed 106 yards rushing on 28 carries and 1 TD for San Francisco and added another 67 yards and TD receiving. At least we know what to expect when each team has the ball. Last defensive stop wins it. The 49ers have covered 8 straight times as underdogs against the Rams. Let’s make it nine. As long as Mac Jones keeps it UNDER 2 turnovers.”

NFL power rankings Week 10: Big shakeup with Colts, Packers, Lions, Chiefs losses

The site’s formula predicts that the Rams will win the NFL Week 10 game against the 49ers.

NFL Week 10 odds: Point spreads, moneylines, over/unders for betting on games this week

ESPN: Rams have a 50% chance to beat 49ers on Sunday

The site gives the 49ers a 49.6% shot at winning the NFL Week 10 game, with the remaining percentage accounting for a tie.

NFL Week 10 schedule: TV channels, how to watch, how to stream games this week

Dimers: 49ers 24, Rams 22

It writes: “After extensive simulations, our model gives the Rams a win probability of 44%, while the 49ers have a win probability of 56%.”

Sportsnaut: Los Angeles Rams 28, San Francisco 49ers 21

Matt Johnson writes: “It took a missed field goal, a missed extra-point attempt, and a lost fumble at the 1-yard line for the Los Angeles Rams to lose in overtime to the San Francisco 49ers in their last meeting on Thursday Night Football. San Francisco’s defense also still had a healthy Fred Warner and Bryce Huff in that game. The 49ers simply don’t have the bodies to beat Los Angeles twice in a season, that is as long as the Rams don’t give the game away to their rival.”

NFL’s highest paid players in 2025: Quarterbacks | Running backs | Wide receivers | Tight ends | Offensive linemen | D-linemen | Cornerbacks | Safeties | Linebackers | Edge rushers | Highest paid NFL players: Overall | By position | By team

Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.

Support local journalism: Subscribe to azcentral.com today. Sign up for azcentral Preps Now. And be sure to subscribe to our daily sports newsletters so you don’t miss a thing.



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