Buffalo (9-2) brings a six-game winning streak into a matchup with San Francisco (5-6) on Sunday, December 1, 2024 at Highmark Stadium. The Bills are the favorites in this one, with the spread sitting at 6.5 points. The over/under for the outing is 44.5 points.
The 49ers lost to the Green Bay Packers, 38-10, in their last contest.
Niners QB Brandon Allen was 17-for-29 for 199 yards, with one TD and one INT, against the Packers.
The Bills’ most recent contest was against the Kansas City Chiefs, and they won by a score of 30-21.
49ers vs Bills betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Sunday at 4:47 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: Buffalo (-6.5)
Moneyline: Buffalo (-285), San Francisco (+231)
Total: 44.5 points
49ers betting insights
San Francisco is 2-3 overall, with only one win against the spread, on the road.
The 49ers are 4-7-0 against the spread this year.
San Francisco is winless ATS (0-1) as 6.5-point underdogs or more away from home.
The 49ers have yet to cover the spread (0-1) when they are at least 6.5-point underdogs.
In three of five road games this year, San Francisco has hit the over.
This year, six 49ers games have gone over the point total.
49ers leaders
Brock Purdy: 2,613 PASS YDS / 261.3 YPG / 66% / 13 TD / 8 INT / 51 CAR / 267 RUSH YDS / 4 TD
Jordan Mason: 140 CAR / 711 YDS / 64.6 YPG / 3 TD / 11 REC / 91 YDS / 8.3 YPG / 0 TD
George Kittle: 49 REC / 642 YDS / 71.3 YPG / 8 TD
Jauan Jennings: 47 REC / 628 YDS / 69.8 YPG / 4 TD
Deebo Samuel: 34 REC / 511 YDS / 51.1 YPG / 1 TD
49ers vs Bills game info
Date: Sunday, December 1, 2024
Time: 8:20 p.m. ET
City: Orchard Park, New York
Venue: Highmark Stadium
TV Channel: NBC
Live Stream: Fubo (Watch Bills vs 49ers on Fubo)
Live Stream: Watch on Peacock
Watch the San Francisco 49ers all season on Fubo!
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