A pair of the best offensive performers in the league will be featured when George Kittle and the San Francisco 49ers host Kyren Williams and the Los Angeles Rams on Thursday, December 12, 2024.
The Rams are generating 22.9 points per game on offense this season (16th-ranked). Meanwhile, they are surrendering 25.5 points per contest (24th-ranked) on defense. The 49ers have been a tough opponent for opposing teams, as they rank top-five in both total offense (fourth-best with 378.5 yards per game) and total defense (third-best with 298.5 yards allowed per game) this season.
Rams vs 49ers: live streaming info, TV channel & game time
Rams vs 49ers betting lines
NFL odds courtesy of BetMGM. Odds updated Thursday at 12:34 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: 49ers (-3)
Moneyline: 49ers (-152), Rams (+127)
Total: 49 points
Watch 49ers vs. Rams on Fubo!
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