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Giants vs. Brewers Prediction, Odds, Picks – April 21

April 20, 2025
inSport
Giants vs. Phillies Highlights | MLB on FOX
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Data Skrive

Sal Frelick and the Milwaukee Brewers take the field on Monday at Oracle Park against Robbie Ray, who will start for the San Francisco Giants. First pitch is set for 9:45 p.m. ET for the first game of a four-game series. The Giants are the favorite in this one, at -149, while the underdog Brewers have +125 odds to play spoiler. San Francisco is a 1.5-run favorite (at +142 odds). The contest’s total has been set at 8 runs.

Here is everything you need to know from a betting perspective on the Giants-Brewers game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Giants vs. Phillies Highlights | MLB on FOX

Check out the best moments between the San Francisco Giants and the Philadelphia Phillies.

Giants vs. Brewers Game Information & Odds

When: Monday, April 21, 2025 at 9:45 p.m. ETWhere: Oracle Park in San Francisco, CaliforniaHow to watch on TV: NBCS-BA and FDSWI Favorite Favorite Moneyline Underdog Moneyline Total Over Total Odds Under Total Odds Run Line Favorite Run Line Odds Underdog Run Line Odds Giants -149 +125 8 -114 -105 -1.5 +142 -169

Giants vs. Brewers Prediction

Score Prediction: Giants 4, Brewers 3Total Prediction: Under 8 runsWin Probabilities: Giants 61%, Brewers 39%

Giants vs. Brewers Betting Insights

The Giants have won seven of the 10 games they’ve played as favorites this season.San Francisco has entered three games this season favored by -149 or more and is 1-2 in those contests.The moneyline for this contest implies a 59.8% chance of a victory for the Giants.The Brewers have been chosen as underdogs in eight games this year and have walked away with the win two times (25%) in those games.This season, Milwaukee has come away with a win one time in four chances when named as an underdog of at least +125 or worse on the moneyline.The Brewers have an implied victory probability of 44.4% according to the moneyline set for this matchup.Milwaukee Brewers

Milwaukee Brewers

MIL

+1.5

+125

O 8

San Francisco Giants

San Francisco Giants

SF

-1.5

-149

U 8

Giants Recent Betting Performance

The Giants were the moneyline favorite for three of their last 10 games, and they finished 2-1 in those matchups.Over their last 10 matchups (all had set totals), the Giants combined with their opponents to hit the over on the run total eight times.The Giants are 5-5-0 against the spread over their past 10 games.

Giants Recent Stats

Stat Avg/Total Record 6-4 Runs Per Game 5.8 HR 12 ERA 4.45 K/9 10.7

Giants Player Insights

Jung Hoo Lee’s .355 average leads the Giants this year. His resume also includes three homers and driven in 14 RBI.In all of Major League Baseball, Lee is 72nd in homers and 29th in RBI.Lee brings a hitting streak of five games into this game. During his last five outings he is batting .471 with two doubles, a walk and three RBI.Wilmer Flores has shown his power as he leads his team with six home runs and 23 RBI.Flores is 11th in homers and third in RBI on the season.Matt James Chapman is batting .250 with three doubles, four home runs and 19 walks.Mike Yastrzemski has six doubles, three home runs and 12 walks while hitting .279.

Brewers Recent Betting Performance

In five games over the last 10 matchups when set as underdogs by sportsbooks, the Brewers had a record of 2-3.In their last 10 games with a total, the Brewers and their opponents have combined to hit the over two times.Over their last 10 games, the Brewers are 6-4-0 against the spread.

Brewers Recent Stats

Stat Avg/Total Record 5-5 Runs Per Game 4.9 HR 9 ERA 2.99 K/9 8.1

Brewers Player Insights

Jackson Chourio leads the Brewers with five long balls and runs batted in, driving in 18.Among all hitters in the majors, Chourio’s home run total is 24th and his RBI tally ranks 11th.Brice Turang is batting .310 with a double, three home runs and four walks.Turang is 72nd in home runs and 78th in RBI among all MLB hitters this year.Frelick leads the Brewers’ lineup with a .319 batting average.William Jesus (Castillo) Contreras is batting .225 with two doubles, three home runs and 11 walks.

Athletics vs. Brewers Highlights | MLB on FOX

Athletics vs. Brewers Highlights | MLB on FOX

Check out the best highlights between the Athletics and the Milwaukee Brewers.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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