The San Francisco Giants (22-13) and the Chicago Cubs (21-14) open a 3-game set Monday. First pitch from Wrigley Field is scheduled for 7:40 p.m. ET. Let’s analyze BetMGM Sportsbook’s MLB odds around the Giants vs. Cubs odds and make our expert MLB picks and predictions for the best bets.
Season series: First meeting; Giants won 4-3 last year
The Giants are coming off a 3-1 series win over the Colorado Rockies in San Francisco, wrapping up the set with a 9-3 victory as -371 favorites Sunday with the Over (7.5) cashing. SS Willy Adames (3-for-5, 3 RBIs) homered twice in the finale, and SP Logan Webb (win, 7 IP, 1 ER, 6 H, 2 BB, 6 K) bounced back after allowing a season-high 5 runs in a 7-4 loss at the San Diego Padres Tuesday.
The Cubs failed to complete a 3-game sweep at the Milwaukee Brewers, losing 4-0 as -108 favorites in the Sunday finale with the Under (8) cashing. SP Shota Imanaga was forced to leave Sunday’s game in the sixth inning after straining his hamstring trying to complete a 1-6-3 double play. Chicago was shut out for the first time since April 11 — a 3-0 loss at the LA Dodgers.
Giants at Cubs projected starters
RHP Landen Roupp vs. LHP Matthew Boyd
Roupp (2-2, 5.10 ERA) makes his seventh start. He has a 1.63 WHIP, 4.2 BB/9 and 10.5 K/9 through 30 innings.
Last start: Loss, 4 1/3 IP, 4 ER, 7 H, 3 BB, 4 K in 5-3 defeat at Padres Wednesday2025 road stats: 2-1, 5.75 ERA (20 1/3 IP, 13 ER), 22 H, 11 BB, 29 K in 4 startsHas never faced Cubs
Boyd (2-2, 2.70 ERA) makes his seventh start. He has a 1.44 WHIP, 3.5 BB/9 and 8.1 K/9 through 33 1/3 innings.
Last start: No-decision, 5 IP, 2 ER, 6 H, 3 BB, 6 K in 4-3 setback at Pittsburgh Pirates Wednesday2025 home stats: 2-0, 2.25 ERA (12 IP, 3 ER), 15 H, 2 BB, 9 K in 2 startsHas never faced Giants — pitched for AL teams from 2015 to 2024
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Giants at Cubs odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 1:28 p.m. ET.
Moneyline (ML): Giants +140 (bet $100 to win $140) | Cubs -170 (bet $170 to win $100)Run line (RL)/Against the spread (ATS): Giants +1.5 (-165) | Cubs -1.5 (+135)Over/Under (O/U): 7.5 (O: +100 | U: -120)
Giants at Cubs picks and predictions
Prediction
Cubs 6, Giants 3
The Cubs (-170) will likely win Monday, but with their advantage at starting pitcher and plus odds on the run line, taking them to win by multiple runs is the preferred play.
PASS on the ML.
Three of the Cubs’ last 4 games have resulted in Chicago wins by 4 or more runs. Additionally, Boyd has been solid at home, winning both starts and allowing just 3 earned runs in 12 innings at Wrigley Field.
Though the Giants are on a 3-game win streak, their last 2 away games — and 5 of their last 8 on the road — have been multi-run losses.
BET CUBS -1.5 (+135).
The Over is 11-1 this season when the Giants are away underdogs, according to TeamRankings.com, and 6-4-1 when the Cubs are home favorites.
Roupp has struggled recently, allowing 7 earned runs in 8 innings across his last 2 starts, and faces a Cubs offense that had scored 6 or more runs in 3 straight games before being held scoreless Sunday at Milwaukee.
BET OVER 7.5 (+100).
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