The San Francisco Giants (45-39) and the Arizona Diamondbacks (41-42) meet for the opener of a 4-game series at Chase Field in Phoenix on Monday. First pitch is scheduled for 9:40 p.m. ET (FS1). Let’s analyze BetMGM Sportsbook’s MLB odds around the Giants vs. Diamondbacks odds and make our expert MLB picks and predictions for the best bets.
Season series: Diamondbacks lead 2-1
The Diamondbacks went into San Francisco and took 2 of 3 games against the Giants at Oracle Park in the first series May 12-14 as the Over cashed in 2 of 3 outings, too. However, both of Monday’s starters, RHP Logan Webb of the Giants and RHP Ryne Nelson of the Diamondbacks, did not pitch in that series.
San Francisco had a stunning power outage on offense in a series loss against the Chicago White Sox on the road over the weekend. The Giants dropped 2 of 3 games, and they managed to score just 5 total runs, including a 1-0 shutout loss Saturday. San Francisco drew 8 walks in Sunday’s series finale, including a pair by DH Rafael Devers, but he also struck out in all 3 official at-bats, and he is hitting just .217 since coming over from Boston in a trade last month.
Meanwhile, Arizona is coming off a stunning 3-game home sweep at the hands of the Miami Marlins. The Snakes have lost 4 in a row, including a 7-3 loss in Chicago against the aforementioned White Sox on Wednesday. The Over has cashed in all 4 games, with Arizona pitching allowing a total of 30 runs in the span, or 7.5 runs per game.
In Sunday’s 6-4 loss, 3B Eugenio Suarez did his part, going 2-for-4 with an RBI, while 2B Ketel Marte launched a solo homer, his 17th of the season, with OF Jake McCarthy recording a triple and an RBI in his 4 at-bats.
Giants at Diamondbacks projected starters
RHP Logan Webb vs. RHP Ryne Nelson
Webb (7-5, 2.52 ERA) makes his 18th start. He has a 1.14 WHIP, 1.9 BB/9 and 10.1 K/9 through 107 1/3 innings.
Last start: No-decision, 6 IP, 2 ER, 6 H, 3 BB, 6 K in 8-5 home loss in 10 innings vs. Marlins Wednesday2025 road stats: 3-4, 3.75 ERA (48 IP, 20 ER), 4 HR, 1.17 WHIP, 10.7 K/9 in 8 starts2024 vs. Diamondbacks: 2-0, 0.00 ERA (13 IP, 0 ER), 6 H, 2 BB, 8 K in 2 starts; has not faced them in 2025Career vs. Diamondbacks: 7-3, 2.31 ERA (74 IP, 19 ER), 2 HR, 19 BB, 59 K, 1.10 WHIP, 7.2 K/9 in 12 starts
Nelson (4-2, 3.71 ERA) makes his 8th start (18th appearance). He has a 1.05 WHIP, 3.1 BB/9 and 7.7 K/9 through 60 2/3 innings.
Last start: No-decision, 5 IP, 1 ER, 1 H (solo HR), 3 BB, 7 K in 4-1 road win vs. Chicago White Sox Tuesday2025 road stats: 1-1, 5.34 ERA (28 2/3 IP, 17 ER), 5 HR, 15 BB, 28 K, 1.15 WHIP, 8.8 K/9 in 4 starts (8 appearances)2025 vs. Giants (1 relief appearance): Hold, 3 IP, 2 ER, 3 H (1 HR), 2 BB, 5 K in 8-7 road win May 14Career vs. Giants: 2-0, 3.11 ERA (37 2/3 IP, 13 ER), 10 BB, 26 K, 1.06 WHIP, 6.2 K/9 in 6 starts (7 appearances)
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Giants at Diamondbacks odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 1:42 p.m. ET.
Moneyline (ML): Giants -130 (bet $130 to win $100) | Diamondbacks +110 (bet $100 to win $110)Run line (RL)/Against the spread (ATS): Giants -1.5 (+125) | Diamondbacks +1.5 (-150)Over/Under (O/U): 8.5 (O: -102 | U: -118)
Giants at Diamondbacks picks and predictions
Prediction
Giants 4, Diamondbacks 3
The GIANTS (-130) are worth playing lightly in this series opener in Phoenix. The Diamondbacks won 2 of 3 in San Francisco back in May, taking a pair of 1-run victories in the series win.
Webb has been pitching well, and he owned the D-backs last season in a pair of starts. However, Nelson has been pitching well lately, allowing just 2 runs in 15 2/3 IP across the past 3 starts, so back San Francisco lightly.
The DIAMONDBACKS +1.5 (-150) are a decent play if you’re a little on the conservative side and you’d like some insurance. Webb has been on fire this season, but he has been rather ordinary at times on the road.
Arizona won a pair of 1-run games in San Francisco back in May, and it should be able to keep things close in a well-pitched game.
UNDER 8.5 (-118) might be the best game in this series opener.
Be careful, though, as Arizona has cashed the Over in each of the past 4 games, with the pitching staff allowing 7.5 runs per game, and at least 6 runs in each of those outings. However, the last Under for Arizona came in Nelson’s most recent start, a 4-1 win in Chicago last Tuesday.
The Under hit in all 3 games in San Francisco this weekend, and the Under is 8-4 across the past 12 games for San Francisco.
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