The San Francisco Giants (47-41) and the A’s (36-53) open a 3-game series Friday. First pitch from Sutter Health Park in West Sacramento is scheduled for 10:05 p.m. ET (MLB Network). Let’s analyze BetMGM Sportsbook’s MLB odds around the Giants vs. A’s odds and make our expert MLB picks and predictions for the best bets.
Season series: Giants lead 3-0
The Giants split 4 games at the Arizona Diamondbacks, wrapping up the set with a 7-2 win Thursday, cashing as -113 favorites with the Over (8.5) hitting for a third straight contest. In the finale, SP Robbie Ray (win, 9 IP, 2 ER, 3 H, 1 BB, 7 K) threw a complete game for the first time since 2017 — back when he was with Arizona. San Francisco has won back-to-back games, but has lost 7 of its last 10 contests.
The A’s won 2 of 3 games at the Tampa Bay Rays, but failed to complete the sweep with a 6-5 loss as +177 underdogs Wednesday with the Over (9) hitting. They rallied for 3 runs in the ninth inning Wednesday to pull within 1, but with the bases loaded, RF Brent Rooker and 1B Nick Kurtz struck out swinging to end the game. The A’s have lost 7 of their last 11 contests.
Giants at A’s projected starters
RHP Justin Verlander vs. LHP JP Sears
Verlander (0-5, 4.26 ERA) makes his 14th start. He has a 1.39 WHIP, 3.3 BB/9 and 7.3 K/9 through 67 2/3 innings.
Last start: No-decision, 6 IP, 1 ER, 5 H, 2 BB, 3 K in 5-2 defeat at Chicago White Sox Sunday2025 road stats: 0-1, 3.58 ERA (27 2/3 IP, 11 ER), 1.30 WHIP, 5.9 K/9 in 5 starts2025 vs. A’s: 1 home start (May 18), no-decision, 4 IP, 2 ER, 3 H, 5 BB, 1 K in 3-2 victoryCareer vs. A’s (regular season): 17-8, 2.64 ERA (190 2/3 IP, 56 ER), 1.04 WHIP, 9.6 K/9 in 30 starts
Sears (6-7, 5.09 ERA) makes his 18th start. He has a 1.30 WHIP, 2.3 BB/9 and 7.0 K/9 through 86 2/3 innings.
Last start: Win, 5 2/3 IP, 0 ER, 2 H, 3 BB, 4 K in 7-0 victory at New York Yankees Saturday2025 home stats: 2-4, 6.68 ERA (32 1/3 IP, 24 ER), 1.55 WHIP, 7.8 K/9 in 7 starts2025 vs. Giants: 1 road start (May 16), loss, 4 IP, 4 ER, 6 H, 3 BB, 2 K in 9-1 defeatCareer vs. Giants: 1-1, 2.41 ERA (18 2/3 IP, 5 ER), 1.07 WHIP, 16 H, 4 BB, 20 K in 3 starts
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Giants at A’s odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:53 a.m. ET.
Moneyline (ML): Giants -110 (bet $110 to win $100) | A’s -110 (bet $110 to win $100)Run line (RL)/Against the spread (ATS): Giants -1.5 (+145) | A’s +1.5 (-175)Over/Under (O/U): 10 (O: -115 | U: -105)
Giants at A’s picks and predictions
Prediction
A’s 6, Giants 5
The A’S (-110) have won 3 of their last 5 games, including a 7-0 victory at the Yankees in Sears’ most recent start. Meanwhile, the Giants have dropped each of Verlander’s last 3 outings and 7 of their last 10 games overall. Back-to-back wins aside, San Francisco still isn’t a team you can count on right now.
BET A’S (-110).
Beating the 20-cent straddle on the ML is more manageable than trying to overcome the heavily juiced run lines.
PASS on the run line.
The Over has hit in each of the Giants’ last 3 games and in 3 of the last 4 for the A’s. San Francisco has scored 6 or more runs in each of its last 2 games, while the A’s have put up 5 or more runs in 4 of their last 5 games.
BET OVER 10 (-115).
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